Publications

Frontoinsular cortical microstructure is linked to life satisfaction in young adulthood

Life satisfaction is a component of subjective well-being that reflects a global judgement of the quality of life according to an …

The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study

We mapped the connections of the insular von Economo neuron (VEN) area in ex vivo brains of a bonobo, an orangutan and two gorillas …

Tractography Processing with the Sparse Closest Point Transform

We propose a novel approach for processing diffusion MRI tractography datasets using the sparse closest point transform (SCPT). …

THC Exposure is Reflected in the Microstructure of the Cerebral Cortex and Amygdala of Young Adults

The endocannabinoid system serves a critical role in homeostatic regulation through its influence on processes underlying appetite, …

Tractography reproducibility challenge with empirical data (traced): The 2017 ismrm diffusion study group challenge

Background. Fiber tracking with diffusion‐weighted MRI has become an essential tool for estimating in vivo brain white matter …

Reinforcement Tractography: a Hybrid Approach for Robust Segmentation of Complex Fiber Bundles

We develop and evaluate a novel hybrid tractography algorithm for improved segmentation of complex fiber bundles from diffusion …

Magnitude and timing of major white matter tract maturation from infancy through adolescence with NODDI

White matter maturation is a nonlinear and heterogeneous phenomenon characterized by axonal packing, increased axon caliber, and a …

Dietary Fructose Intake and Hippocampal Structure and Connectivity during Childhood

In rodent literature, there is evidence that excessive fructose consumption during development has a detrimental impact on hippocampal …

A Computational diffusion MRI framework for biomarker discovery in a rodent model of post-traumatic epileptogenesis

Epilepsy is a debilitating neurological disorder that directly impacts millions of people and exerts a tremendous economic burden on …

Rapid and Accurate NODDI Parameter Estimation with the Spherical Mean Technique

Neurite orientation dispersion and density imaging (NODDI) is a widely used tool for modeling microstructure using diffusion MRI, but …

Perivascular space fluid contributes to diffusion tensor imaging changes in white matter

Diffusion tensor imaging (DTI) has been extensively used to map changes in brain tissue related to neurological disorders. Among the …

Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease

Introduction. Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer’s disease pathology, the …

MicroQIT - A Computational Framework for Population Microstructure Imaging

Microstructure imaging provides a quantitative tool for characterizing neural tissue with diffusion MRI and expanding our understanding …

Limits to anatomical accuracy of diffusion tractography using modern approaches

Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the brain, with a range of applications in both …

Image processing approaches to enhance perivascular space visibility and quantification using MRI

Imaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant clinical value, but there remains a need for …

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Preclinical imaging studies of posttraumatic epileptogenesis (PTE) have largely been proof-of-concept studies with limited animal …

Clinical 7 T MRI: Are we there yet? A review about magnetic resonance imaging at ultra-high field

In recent years, ultra-high field MRI (7 T and above) has received more interest for clinical imaging. Indeed, a number of studies have …

Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults

Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The …

White matter fiber bundle lengths are shorter in cART naive HIV: an analysis of quantitative diffusion tractography in South Africa

This study examines white matter microstructure using quantitative tractography diffusion magnetic resonance imaging (qtdMRI) in HIV+ …

Quantitative Imaging Toolkit: Software for Interactive 3D Visualization, Data Exploration, and Computational Analysis of Neuroimaging Datasets

Computational tools are increasingly important to MR imaging research, as they can make experiments more reproducible, improve our …

Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging

This study investigates multimodal structural MR imaging biomarkers of development trajectories in pediatric bipolar disorder. …

Neuroanatomical morphometric characterization of sex differences in youth using statistical learning

Exploring neuroanatomical sex differences using a multivariate statistical learning approach can yield insights that cannot be derived …

Identifying potential biomarkers of epileptogenesis after traumatic brain injury using human EEG data and animal models

Epilepsy is among the most common serious disabling disorders of the brain, and the global burden of epilepsy exerts a tremendous cost …

Feasibility of Quantitative Diffusion MR Tractography of the Vestibulocochlear Nerve in Children with Unilateral Profound Sensorineural Hearing Loss

Diffusion MR tractography modeling of the vestibulocochlear nerve (VCN) has clinical value for characterizing hearing loss and surgical …

Analytic tools for post-traumatic epileptogenesis biomarker search in multimodal dataset of an animal model and human patients

Epilepsy is among the most common serious disabling disorders of the brain, and the global burden of epilepsy exerts a tremendous cost …

Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging

Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. …

Topological organization of whole-brain white matter in HIV infection

Infection with human immunodeficiency virus (HIV) is associated with neuroimaging alterations. However, little is known about the …

Neuroimaging biomarkers of cognitive decline in healthy older adults via unified learning

Cognitive aging in healthy adults exhibits significant and heterogeneous variability. In this study, we apply a robust unified learning …

Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity

Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, …

In vivo exploration of the connectivity between the subthalamic nucleus and the globus pallidus in the human brain using multi-fiber tractography

The basal ganglia is part of a complex system of neuronal circuits that play a key role in the integration and execution of motor, …

Cognitive reserve moderates the relationship between neuropsychological performance and white matter fiber bundle length in healthy older adults

Recent work using novel neuroimaging methods has revealed shorter white matter fiber bundle length (FBL) in older compared to younger …

A Comparative evaluation of voxel-based spatial mapping in diffusion tensor imaging

This paper presents a comparative evaluation of methods for automated voxel-based spatial mapping in diffusion tensor imaging studies. …

Regional age differences in gray matter diffusivity among healthy older adults

Aging is associated with microstructural changes in brain tissue that can be visualized using diffusion tensor imaging (DTI). While …

Reducing CSF partial volume effects to enhance diffusion tensor imaging metrics of brain microstructure

Technological advances over recent decades now allow for in vivo observation of human brain tissue through the use of neuroimaging …

Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: a comprehensive assessment of white matter integrity and cognition

The common angiotensinogen (AGT) M268T polymorphism (rs699; historically referred to as M235T) has been identified as a significant …

Kernel regression estimation of fiber orientation mixtures in diffusion MRI

We present and evaluate a method for kernel regression estimation of fiber orientations and associated volume fractions for diffusion …

Fauxvea: Crowdsourcing gaze location estimates for visualization analysis tasks

We present the design and evaluation of a method for estimating gaze locations during the analysis of static visualizations using …

Application of a novel quantitative tractography-based analysis of diffusion tensor imaging to examine fiber bundle length in human cerebral white matter

This paper reviews basic methods and recent applications of length-based fiber bundle analysis of cerebral white matter using diffusion …

Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment

Objective. Much of the mild cognitive impairment (MCI) neuroimaging literature has exclusively focused on regions associated with …

Genetic markers of cholesterol transport and gray matter diffusion: a preliminary study of the CETP I405V polymorphism

Variations of the cholesteryl ester transfer protein polymorphism (CETP I405V/rs5882) have been associated with an increased risk for …

Fiber bundle length and cognition: a length-based tractography MRI study

Executive function (EF) and cognitive processing speed (CPS) are two cognitive performance domains that decline with advanced age. …

Brain structure and cognitive correlates of body mass index in healthy older adults

Obesity, commonly measured with body mass index (BMI), is associated with numerous deleterious health conditions including alterations …

White matter changes with age utilizing quantitative diffusion MRI

OBJECTIVE: To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific …

Diffusion Tractography of the Corticospinal Tract with Multi-fiber Orientation Filtering

The reconstruction of the corticospinal tract in the human brain is a clinically important task for both surgical planning and …

Bilateral Filtering of Multiple Fiber Orientations in Diffusion MRI

We present and evaluate a bilateral filter for smoothing diffusion MRI fiber orientations with preservation of anatomical boundaries …

White Matter Supervoxel Segmentation by Axial DP-means Clustering

A powerful aspect of diffusion MR imaging is the ability to reconstruct fiber orientations in brain white matter; however, the …

Neuronal fiber bundle lengths in healthy adult carriers of the ApoE4 allele: a quantitative tractography DTI study

The epsilon 4 (e4) isoform of apolipoprotein E (ApoE) is a known genetic risk factor for suboptimal brain health. Morphometry studies …

Impact of body mass index on neuronal fiber bundle lengths among healthy older adults

Increased body mass index (BMI) has been linked to various detrimental health outcomes, including cognitive dysfunction. Recent work …

Estimating constrained multi-fiber diffusion MR volumes by orientation clustering

Diffusion MRI is a valuable tool for mapping tissue microstructure; however, multi-fiber models present challenges to image analysis …

A Diffusion MRI Resource of 80 Age-varied Subjects with Neuropsychological and Demographic Measures

The primary purpose of this work is to provide a resource of high angular resolution diffusion MRI datasets of 80 normal volunteers …

The measurement of local variation in shape

Geometric morphometrics comprises tools for measuring and analyzing shape as captured by an entire set of landmark configurations. Many …

Diffeomorphic sulcal shape analysis on the cortex

We present a diffeomorphic approach for constructing intrinsic shape atlases of sulci on the human cortex. Sulci are represented as …

Mapping corticocortical structural integrity in schizophrenia and effects of genetic liability

Background. Structural and diffusion tensor imaging studies implicate gray and white matter (WM) abnormalities and disruptions of …

Diffeomorphic sulcal shape analysis for cortical surface registration

We present an intrinsic framework for constructing sulcal shape atlases on the human cortex. We propose the analysis of sulcal and …

Cortical sulcal atlas construction using a diffeomorphic mapping approach

We present a geometric approach for constructing shape atlases of sulcal curves on the human cortex. Sulci and gyri are represented as …