Image-based Stroke Assessment for Multi-site Preclinical Evaluation of Cerebroprotectants
Ischemic stroke is a leading cause of death worldwide, but there has been little success translating putative cerebroprotectants from …
Mapping frontoinsular cortex from diffusion microstructure
We developed a novel method for mapping the location, surface area, thickness, and volume of frontoinsular cortex (FI) using structural …
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results
Cerebral ischemia and reperfusion initiate cellular events in brain that lead to neurological disability. Investigating these cellular …
Life after mild traumatic brain injury: Widespread structural brain changes associated with psychological distress revealed with multimodal magnetic resonance imaging
Traumatic brain injury (TBI) can alter brain structure and lead to onset of persistent neuropsychological symptoms. This study …
Anatomical and topographical variations in the distribution of brain metastases based on primary cancer origin and molecular subtypes: a systematic review
While it has been suspected that different primary cancers have varying predilections for metastasis in certain brain regions, recent …
Evaluating U-net Brain Extraction for Multi-site and Longitudinal Preclinical Stroke Imaging
Rodent stroke models are important for evaluating treatments and understanding the pathophysiology and behavioral changes of brain …
Frontoinsular cortical microstructure is linked to life satisfaction in young adulthood
Life satisfaction is a component of subjective well-being that reflects a global judgement of the quality of life according to an …
Tractography dissection variability: what happens when 42 groups dissect 14 white matter bundles on the same dataset?
White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber …
Microstructural properties within the amygdala and affiliated white matter tracts across adolescence
The amygdala is a heterogenous set of nuclei with widespread cortical connections that continues to develop postnatally with vital …
Connectivity characterization of the mouse basolateral amygdalar complex
The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have …
The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study
We mapped the connections of the insular von Economo neuron (VEN) area in ex vivo brains of a bonobo, an orangutan and two gorillas …
Tractography Processing with the Sparse Closest Point Transform
We propose a novel approach for processing diffusion MRI tractography datasets using the sparse closest point transform (SCPT). …
THC Exposure is Reflected in the Microstructure of the Cerebral Cortex and Amygdala of Young Adults
The endocannabinoid system serves a critical role in homeostatic regulation through its influence on processes underlying appetite, …
Tractography reproducibility challenge with empirical data (traced): The 2017 ismrm diffusion study group challenge
Background. Fiber tracking with diffusion‐weighted MRI has become an essential tool for estimating in vivo brain white matter …
Reinforcement Tractography: a Hybrid Approach for Robust Segmentation of Complex Fiber Bundles
We develop and evaluate a novel hybrid tractography algorithm for improved segmentation of complex fiber bundles from diffusion …
Magnitude and timing of major white matter tract maturation from infancy through adolescence with NODDI
White matter maturation is a nonlinear and heterogeneous phenomenon characterized by axonal packing, increased axon caliber, and a …
Dietary Fructose Intake and Hippocampal Structure and Connectivity during Childhood
In rodent literature, there is evidence that excessive fructose consumption during development has a detrimental impact on hippocampal …
A Computational diffusion MRI framework for biomarker discovery in a rodent model of post-traumatic epileptogenesis
Epilepsy is a debilitating neurological disorder that directly impacts millions of people and exerts a tremendous economic burden on …
Rapid and Accurate NODDI Parameter Estimation with the Spherical Mean Technique
Neurite orientation dispersion and density imaging (NODDI) is a widely used tool for modeling microstructure using diffusion MRI, but …
Perivascular space fluid contributes to diffusion tensor imaging changes in white matter
Diffusion tensor imaging (DTI) has been extensively used to map changes in brain tissue related to neurological disorders. Among the …
Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease
Introduction. Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer’s disease pathology, the …
MicroQIT - A Computational Framework for Population Microstructure Imaging
Microstructure imaging provides a quantitative tool for characterizing neural tissue with diffusion MRI and expanding our understanding …
Limits to anatomical accuracy of diffusion tractography using modern approaches
Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the brain, with a range of applications in both …
Image processing approaches to enhance perivascular space visibility and quantification using MRI
Imaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant clinical value, but there remains a need for …
Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis
Preclinical imaging studies of posttraumatic epileptogenesis (PTE) have largely been proof-of-concept studies with limited animal …
Clinical 7 T MRI: Are we there yet? A review about magnetic resonance imaging at ultra-high field
In recent years, ultra-high field MRI (7 T and above) has received more interest for clinical imaging. Indeed, a number of studies have …
Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults
Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The …
White matter fiber bundle lengths are shorter in cART naive HIV: an analysis of quantitative diffusion tractography in South Africa
This study examines white matter microstructure using quantitative tractography diffusion magnetic resonance imaging (qtdMRI) in HIV+ …
Quantitative Imaging Toolkit: Software for Interactive 3D Visualization, Data Exploration, and Computational Analysis of Neuroimaging Datasets
Computational tools are increasingly important to MR imaging research, as they can make experiments more reproducible, improve our …
Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging
This study investigates multimodal structural MR imaging biomarkers of development trajectories in pediatric bipolar disorder. …
Neuroanatomical morphometric characterization of sex differences in youth using statistical learning
Exploring neuroanatomical sex differences using a multivariate statistical learning approach can yield insights that cannot be derived …
Identifying potential biomarkers of epileptogenesis after traumatic brain injury using human EEG data and animal models
Epilepsy is among the most common serious disabling disorders of the brain, and the global burden of epilepsy exerts a tremendous cost …
Feasibility of Quantitative Diffusion MR Tractography of the Vestibulocochlear Nerve in Children with Unilateral Profound Sensorineural Hearing Loss
Diffusion MR tractography modeling of the vestibulocochlear nerve (VCN) has clinical value for characterizing hearing loss and surgical …
Analytic tools for post-traumatic epileptogenesis biomarker search in multimodal dataset of an animal model and human patients
Epilepsy is among the most common serious disabling disorders of the brain, and the global burden of epilepsy exerts a tremendous cost …
Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging
Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. …
Topological organization of whole-brain white matter in HIV infection
Infection with human immunodeficiency virus (HIV) is associated with neuroimaging alterations. However, little is known about the …
Neuroimaging biomarkers of cognitive decline in healthy older adults via unified learning
Cognitive aging in healthy adults exhibits significant and heterogeneous variability. In this study, we apply a robust unified learning …
Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity
Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, …
In vivo exploration of the connectivity between the subthalamic nucleus and the globus pallidus in the human brain using multi-fiber tractography
The basal ganglia is part of a complex system of neuronal circuits that play a key role in the integration and execution of motor, …
Cognitive reserve moderates the relationship between neuropsychological performance and white matter fiber bundle length in healthy older adults
Recent work using novel neuroimaging methods has revealed shorter white matter fiber bundle length (FBL) in older compared to younger …
A Comparative evaluation of voxel-based spatial mapping in diffusion tensor imaging
This paper presents a comparative evaluation of methods for automated voxel-based spatial mapping in diffusion tensor imaging studies. …
Regional age differences in gray matter diffusivity among healthy older adults
Aging is associated with microstructural changes in brain tissue that can be visualized using diffusion tensor imaging (DTI). While …
Reducing CSF partial volume effects to enhance diffusion tensor imaging metrics of brain microstructure
Technological advances over recent decades now allow for in vivo observation of human brain tissue through the use of neuroimaging …
Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: a comprehensive assessment of white matter integrity and cognition
The common angiotensinogen (AGT) M268T polymorphism (rs699; historically referred to as M235T) has been identified as a significant …
Kernel regression estimation of fiber orientation mixtures in diffusion MRI
We present and evaluate a method for kernel regression estimation of fiber orientations and associated volume fractions for diffusion …
Fauxvea: Crowdsourcing gaze location estimates for visualization analysis tasks
We present the design and evaluation of a method for estimating gaze locations during the analysis of static visualizations using …
Application of a novel quantitative tractography-based analysis of diffusion tensor imaging to examine fiber bundle length in human cerebral white matter
This paper reviews basic methods and recent applications of length-based fiber bundle analysis of cerebral white matter using diffusion …
Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment
Objective. Much of the mild cognitive impairment (MCI) neuroimaging literature has exclusively focused on regions associated with …
Genetic markers of cholesterol transport and gray matter diffusion: a preliminary study of the CETP I405V polymorphism
Variations of the cholesteryl ester transfer protein polymorphism (CETP I405V/rs5882) have been associated with an increased risk for …
Fiber bundle length and cognition: a length-based tractography MRI study
Executive function (EF) and cognitive processing speed (CPS) are two cognitive performance domains that decline with advanced age. …
Brain structure and cognitive correlates of body mass index in healthy older adults
Obesity, commonly measured with body mass index (BMI), is associated with numerous deleterious health conditions including alterations …
White matter changes with age utilizing quantitative diffusion MRI
OBJECTIVE: To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific …
Diffusion Tractography of the Corticospinal Tract with Multi-fiber Orientation Filtering
The reconstruction of the corticospinal tract in the human brain is a clinically important task for both surgical planning and …
Bilateral Filtering of Multiple Fiber Orientations in Diffusion MRI
We present and evaluate a bilateral filter for smoothing diffusion MRI fiber orientations with preservation of anatomical boundaries …
White Matter Supervoxel Segmentation by Axial DP-means Clustering
A powerful aspect of diffusion MR imaging is the ability to reconstruct fiber orientations in brain white matter; however, the …
Neuronal fiber bundle lengths in healthy adult carriers of the ApoE4 allele: a quantitative tractography DTI study
The epsilon 4 (e4) isoform of apolipoprotein E (ApoE) is a known genetic risk factor for suboptimal brain health. Morphometry studies …
Impact of body mass index on neuronal fiber bundle lengths among healthy older adults
Increased body mass index (BMI) has been linked to various detrimental health outcomes, including cognitive dysfunction. Recent work …
Estimating constrained multi-fiber diffusion MR volumes by orientation clustering
Diffusion MRI is a valuable tool for mapping tissue microstructure; however, multi-fiber models present challenges to image analysis …
A Diffusion MRI Resource of 80 Age-varied Subjects with Neuropsychological and Demographic Measures
The primary purpose of this work is to provide a resource of high angular resolution diffusion MRI datasets of 80 normal volunteers …
The measurement of local variation in shape
Geometric morphometrics comprises tools for measuring and analyzing shape as captured by an entire set of landmark configurations. Many …
Diffeomorphic sulcal shape analysis on the cortex
We present a diffeomorphic approach for constructing intrinsic shape atlases of sulci on the human cortex. Sulci are represented as …
Mapping corticocortical structural integrity in schizophrenia and effects of genetic liability
Background. Structural and diffusion tensor imaging studies implicate gray and white matter (WM) abnormalities and disruptions of …
Diffeomorphic sulcal shape analysis for cortical surface registration
We present an intrinsic framework for constructing sulcal shape atlases on the human cortex. We propose the analysis of sulcal and …
Cortical sulcal atlas construction using a diffeomorphic mapping approach
We present a geometric approach for constructing shape atlases of sulcal curves on the human cortex. Sulci and gyri are represented as …